Study of NX-5948 Versus Pirtobrutinib in R/R CLL/SLL

NCT07516093Phase 3Recruiting

Lead sponsor
Nurix Therapeutics, Inc. (Industry)
Enrollment
620 (estimated)
Start date
3 Aug 2026
Primary completion
Oct 2029 (estimated)
Study completion
1 Aug 2033
Last update posted
31 Aug 2026

Design

Study type
Interventional
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel
Masking
None
Arms
2

Interventions

  • NX-5948 Drug
  • Pirtobrutinib Drug

Conditions and primary outcome

  • B-cell Lymphoma
  • Chronic Lymphocytic Leukemia
  • Small Lymphocytic Lymphoma

Primary outcome

Progression-free survival (PFS) as assessed by Independent Review Committee (IRC) (Up to approximately 3.5 years); Objective response rate (ORR) without partial response with lymphocytosis (PR-L) as assessed by IRC (Up to approximately 2.5 years)

Posted results on ClinicalTrials.gov

Results posted on ClinicalTrials.gov: No

Results from company and journal sources

No editor-confirmed results are on record for this study.

Publications

No PubMed citation lists NCT07516093.

CT-VCA trial quality

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Data integrity

Compare what the registry, company releases, FDA documents and publications say about this study.

Drugs on HealthTrade

Source

Source: ClinicalTrials.gov, U.S. National Library of Medicine. Listing a study does not mean NLM has evaluated it.

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